一次外出公干中，艾利克斯（马修·派瑞 Matthew Perry 饰）遇见了名为伊莎贝尔（萨尔玛·海耶克 Salma Hayek 饰）的摄影师，伊莎贝尔的美丽和奔放吸引了艾利克斯的注意，两人之间产生了一段充满了激情和浪漫的露水情缘。
本以为这段情缘不过是漫长生命中的小小点缀，但令艾利克斯没有想到的是，几个月之后，他竟然和伊莎贝尔在内华达州重逢了，不仅如此，此时的伊莎贝尔腹中，已经怀上了艾利克斯的骨肉。事已至此，艾利克斯决定同伊莎贝尔结婚，而这对“最亲密的陌生人”，他们能够处理好彼此之间的感情吗？随着时间的推移，艾利克斯和伊莎贝尔之间产生了巨大的分歧，他们一个希望能够回到纽约，一个想要留在内华达州，在巨大的个性差异面前，他们还能够坚持自己的选择吗？
Lewis returns to Oxford after several years absence and is reluctantly assigned by his new boss, DCS Innocent, to the murder of an Oxford mathematics student who was shot while participating in a sleep study. The key-code used to access the sleep lab was assigned to a fellow maths student, Daniel Griffin, but Daniel's math tutor has provided him with an alibi. Daniel is a maladjusted young man who will soon inherit his father's automotive empire. He is disruptive and has no respect for his uncle who now heads the company. The future of the company however rests on an impending deal with Japanese investors who insist that family unity is all important at this time. When two other murder occurs, Lewis must decipher a cryptic clue left in an old case file by his former boss, Chief Inspector Morse.
